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Article

Unveiling the molecular pathogenesis of chordoma: a new paradigm for molecular targeting of rare cancers.

The Journal of pathology - 1 Apr 2011

Dei Tos Angelo Paolo

Abstract excerpt

'Chordoma' represents orphan sarcoma subtypes in which systemic treatments have so far proved ineffective. Two original papers in the Journal of Pathology have recently elucidated important steps of its molecular oncogenesis. The demonstration of gains of copy number of both T (brachyury homologue) and EGFR (epidermal growth factor receptor) genes in chordoma, as well as of their role in promoting cell...

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Identifiers

PMID: 21394718
DOI: 10.1002/path.2847

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Unveiling the molecular pathogenesis of chordoma: a new paradigm for molecular targeting of rare cancers.PMID 21394718Read ↗

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Recent advances in understanding and managing chordomas: an updateSemantic proximity Read ↗

The role of epidermal growth factor receptor in chordoma pathogenesis: a potential therapeutic target.Semantic proximity Read ↗

Mapping the landscape of genetic dependencies in chordomaSemantic proximity Read ↗

Selective targeting of TBXT with DARPins identifies regulatory networks and therapeutic vulnerabilities in chordomaSemantic proximity Read ↗

From Histology to Multi-Omics: Review of Chordoma Classification and Its Clinical ImplicationsSemantic proximity Read ↗

Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.Semantic proximity Read ↗

Establishment and detailed functional and molecular genetic characterisation of a novel sacral chordoma cell line, MUG-Chor1.Semantic proximity Read ↗

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