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Article

Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.

Journal of neurochemistry - 1 Mar 2012

Hebbring Scott J, Chai Yubo, Ji Yuan, Abo Ryan P, Jenkins Gregory D, Fridley Brooke, Zhang Jianping, Eckloff Bruce W, Wieben Eric D, Weinshilboum Richard M

Abstract excerpt

Serine hydroxymethyltransferase (SHMT) catalyzes the transfer of a β-carbon from serine to tetrahydrofolate to form glycine and 5,10-methylene-tetrahydrofolate. This reaction plays an important role in neurotransmitter synthesis and metabolism. We set out to resequence SHMT1 and SHMT2, followed by functional genomic studies. We identified 87 and 60 polymorphisms in SHMT1 and SHMT2, respectively. We observed no...

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Identifiers

PMID: 22220685
DOI: 10.1111/j.1471-4159.2012.07646.x
PMCID: PMC3296836

Genes

SHMT1
SHMT2

Provenance

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