Article

Identification of novel pathogenic roles of BLZF1/ATF6 in tumorigenesis of gastrointestinal stromal tumor mediated by Golgi-localized mutant KIT

2022-09-22

Abstract excerpt

<h4>Background: </h4> Gastrointestinal stromal tumors (GISTs) frequently show KIT mutations, accompanied by overexpression and aberrant localization of mutant KIT (MT-KIT). However, it remains unclear how MT-KIT contributes to GIST pathogenesis. Methods To evaluate the expression, localization and stability of wild type KIT (WT-KIT) and MT-KIT, we performed western blotting, biotinylation assays and confocal micr...

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Literature Corpus work: b1e5cb2a-15e3-5c04-808b-f37b30898326
DOI: 10.21203/rs.3.rs-2081674/v1

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