Article

High-dose Vitamin C Blocks HOCl Production by Myeloperoxidase: A Potential Therapeutic Strategy

2024-12-05

Abstract excerpt

High-dose vitamin C therapy for cancer, originally advocated by Linus Pauling (Proc Natl Acad Sci, 1976, 73, 3685–3689), remains a subject of ongoing debate. In this study, we investigate why only pharmacological doses are effective and explore the reasons behind inconsistent therapeutic outcomes. Our data suggest that the bona fide cause of toxicity was oxidized vitamin C rather than hydrogen peroxide. We found t...

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Literature Corpus work: 2ee7902b-3ef3-546b-8dc4-c9bc6fbf1b9c
DOI: 10.1101/2024.12.05.627077

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