Article
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
Nature genetics - 1 Oct 2017
Zhao Wei, Rasheed Asif, Tikkanen Emmi, Lee Jung-Jin, Butterworth Adam S, Howson Joanna M M, Assimes Themistocles L, Chowdhury Rajiv, Orho-Melander Marju, Damrauer Scott, Small Aeron, Asma Senay, Imamura Minako, Yamauch Toshimasa, Chambers John C, Chen Peng, Sapkota Bishwa R, Shah Nabi, Jabeen Sehrish, Surendran Praveen, Lu Yingchang, Zhang Weihua, Imran Atif, Abbas Shahid, Majeed Faisal, Trindade Kevin, Qamar Nadeem, Mallick Nadeem Hayyat, Yaqoob Zia, Saghir Tahir, Rizvi Syed Nadeem Hasan, Memon Anis, Rasheed Syed Zahed, Memon Fazal-Ur-Rehman, Mehmood Khalid, Ahmed Naveeduddin, Qureshi Irshad Hussain, Tanveer-Us-Salam, Iqbal Wasim, Malik Uzma, Mehra Narinder, Kuo Jane Z, Sheu Wayne H-H, Guo Xiuqing, Hsiung Chao A, Juang Jyh-Ming J, Taylor Kent D, Hung Yi-Jen, Lee Wen-Jane, Quertermous Thomas, Lee I-Te, Hsu Chih-Cheng, Bottinger Erwin P, Ralhan Sarju, Teo Yik Ying, Wang Tzung-Dau, Alam Dewan S, Di Angelantonio Emanuele, Epstein Steve, Nielsen Sune F, Nordestgaard Børge G, Tybjaerg-Hansen Anne, Young Robin, Benn Marianne, Frikke-Schmidt Ruth, Kamstrup Pia R, Jukema J Wouter, Sattar Naveed, Smit Roelof, Chung Ren-Hua, Liang Kae-Woei, Anand Sonia, Sanghera Dharambir K, Ripatti Samuli, Loos Ruth J F, Kooner Jaspal S, Tai E Shyong, Rotter Jerome I, Chen Yii-Der Ida, Frossard Philippe, Maeda Shiro, Kadowaki Takashi, Reilly Muredach, Pare Guillaume, Melander Olle, Salomaa Veikko, Rader Daniel J, Danesh John, Voight Benjamin F, Saleheen Danish
Abstract excerpt
To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D and 260,365 subjects for CHD. We identify 16 previously unreported loci for T2D and 1 locus for CHD, including a new T2D association at a missense variant in HLA-DRB5 (odds ratio (OR) = 1.29). We...
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