Article

Replicable generation of rhesus macaque iPSCs for <i>in vitro</i> modeling of genetic frontotemporal dementia

2026-03-18

Abstract excerpt

At the Wisconsin National Primate Research Center, we have identified a family of rhesus carrying the microtubule-associated protein tau ( MAPT ) R406W mutation linked to frontotemporal dementia (FTD). Rhesus induced pluripotent stem cells (RhiPSCs) derived from these monkeys present a unique opportunity for in vitro modeling and comparison with cells derived from MAPT R406W human carriers. Here, we report the...

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Literature Corpus work: b12ffcd0-b444-51bc-8b7a-10e3c03f6da5
DOI: 10.64898/2026.03.17.712482

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