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Article

DNA methylation signatures in airway cells from adult children of asthmatic mothers reflect subtypes of severe asthma

6 Jun 2022

Abstract excerpt

Maternal asthma (MA) is among the most consistent risk factors for asthma in children. Possible mechanisms for this observation are epigenetic modifications in utero that have lasting effects on developmental programs in children of mothers with asthma. To test this hypothesis, we performed differential DNA methylation analyses of 398,186 individual CpG sites in primary bronchial epithelial cells (BECs) from 42...

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PMID: 35666868
DOI: 10.1073/pnas.2116467119

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