Article

Single cell RNA-seq discovery of blood biomarkers predicting treatment outcome in severe asthma patients

2025-04-17

Abstract excerpt

Biologic monoclonal antibody therapies for severe asthma target the Type 2 endotype through blockade of the IgE, IL-5/eosinophil, or IL-4/13 pathways, which represents at least two-thirds of patients, and have led to significant clinical benefits in severe asthma management. However, studies show that 10-20% of patients may be non-responders and require a change in therapy. There is also the emerging concept that...

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Literature Corpus work: 98bc4e46-1273-5c17-b26d-4dfb6f252140
DOI: 10.1101/2025.04.16.25325934

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