Article

Experimental Evolution Reveals Redox State Modulates Mycobacterial Pathogenicity

2021-12-24

Abstract excerpt

<h4>ABSTRACT</h4> Understanding how Mycobacterium tuberculosis has evolved into a professional pathogen is helpful in studying its pathogenesis and for designing vaccines. We investigated how the evolutionary adaptation of M. smegmatis mc 2 51 to an important clinical stressor H 2 O 2 allows bacteria undergo coordinated genetic mutations, resulting in increased pathogenicity. Whole-genome sequencing identifi...

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Literature Corpus work: f8fc693a-048e-56d4-811c-7ce9689d3781
DOI: 10.1101/2021.12.23.474061

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