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Article

Optimization of Conformational Dynamics in an Epistatic Evolutionary Trajectory.

Molecular biology and evolution - 1 Jul 2016

González Mariano M, Abriata Luciano A, Tomatis Pablo E, Vila Alejandro J

Abstract excerpt

The understanding of protein evolution depends on the ability to relate the impact of mutations on molecular traits to organismal fitness. Biological activity and robustness have been regarded as important features in shaping protein evolutionary landscapes. Conformational dynamics, which is essential for protein function, has received little attention in the context of evolutionary analyses. Here we employ NMR...

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Share to beta-Lactamases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Directed Molecular Evolution

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Identifiers

PMID: 26983555
DOI: 10.1093/molbev/msw052
PMCID: PMC5854100

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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