Article
The Calcilytic Agent NPS 2143 Rectifies Hypocalcemia in a Mouse Model With an Activating Calcium-Sensing Receptor (CaSR) Mutation: Relevance to Autosomal Dominant Hypocalcemia Type 1 (ADH1).
Endocrinology - 1 Sept 2015
Hannan Fadil M, Walls Gerard V, Babinsky Valerie N, Nesbit M Andrew, Kallay Enikö, Hough Tertius A, Fraser William D, Cox Roger D, Hu Jianxin, Spiegel Allen M, Thakker Rajesh V
Abstract excerpt
Autosomal dominant hypocalcemia type 1 (ADH1) is caused by germline gain-of-function mutations of the calcium-sensing receptor (CaSR) and may lead to symptomatic hypocalcemia, inappropriately low serum PTH concentrations and hypercalciuria. Negative allosteric CaSR modulators, known as calcilytics, have been shown to normalize the gain-of-function associated with ADH-causing CaSR mutations in vitro and represent...
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