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Article

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.

The Journal of biological chemistry - 20 Feb 2004

Miedlich Susanne U, Gama Lucio, Seuwen Klaus, Wolf Romain M, Breitwieser Gerda E

Abstract excerpt

A homology model for the human calcium sensing receptor (hCaR) transmembrane domain utilizing bovine rhodopsin (bRho) structural information was derived and tested by docking the allosteric antagonist, NPS 2143, followed by mutagenesis of predicted contact sites. Mutation of residues Phe-668 (helix II), Arg-680, or Phe-684 (helix III) to Ala (or Val or Leu) and Glu-837 (helix VII) to Ile (or Gln) reduced the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 14660633
DOI: 10.1074/jbc.M307191200

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NPS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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