Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.

doi:10.1074/jbc.M307191200

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.

The Journal of biological chemistry - 20 Feb 2004

Miedlich Susanne U, Gama Lucio, Seuwen Klaus, Wolf Romain M, Breitwieser Gerda E

Abstract excerpt

A homology model for the human calcium sensing receptor (hCaR) transmembrane domain utilizing bovine rhodopsin (bRho) structural information was derived and tested by docking the allosteric antagonist, NPS 2143, followed by mutagenesis of predicted contact sites. Mutation of residues Phe-668 (helix II), Arg-680, or Phe-684 (helix III) to Ala (or Val or Leu) and Glu-837 (helix VII) to Ile (or Gln) reduced the...

Topics

Allosteric Site
Amino Acid Sequence
Animals
Binding Sites
Calcium
Cattle
Cell Line
Cell Membrane
Dose-Response Relationship, Drug
Enzyme-Linked Immunosorbent Assay
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ligands

Models, Chemical

Models, Molecular

Molecular Sequence Data

Mutagenesis, Site-Directed

Mutation

Point Mutation

Source

Open in PubMed

Identifiers

PMID: 14660633
DOI: 10.1074/jbc.M307191200

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Homology modeling of the transmembrane domain of the human calcium sensing receptor and localization of an allosteric binding site.PMID 14660633Read ↗

Structure and function of the human calcium-sensing receptor: insights from natural and engineered mutations and allosteric modulators.Semantic proximity Read ↗

Towards a structural understanding of allosteric drugs at the human calcium-sensing receptor.Semantic proximity Read ↗

Recent advances in calcium-sensing receptor structures and signaling pathways.Semantic proximity Read ↗

Structure and function of the extracellular calcium-sensing receptor (Review).Semantic proximity Read ↗

Impact of clinically relevant mutations on the pharmacoregulation and signaling bias of the calcium-sensing receptor by positive and negative allosteric modulators.Semantic proximity Read ↗

Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations.Semantic proximity Read ↗

Calmodulin regulates Ca2+-sensing receptor-mediated Ca2+ signaling and its cell surface expression.Semantic proximity Read ↗

Structure-function relationship of the extracellular calcium-sensing receptor.Semantic proximity Read ↗

Delineating a Ca2+ binding pocket within the venus flytrap module of the human calcium-sensing receptor.Semantic proximity Read ↗

Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist.Semantic proximity Read ↗

Evolutionary History of Calcium-Sensing Receptors Unveils Hyper/Hypocalcemia-Causing MutationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.