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Article

Calcimimetic and calcilytic therapies for inherited disorders of the calcium‐sensing receptor signalling pathway

11 Nov 2017

Abstract excerpt

The calcium‐sensing receptor (CaS receptor) plays a pivotal role in extracellular calcium homeostasis, and germline loss‐of‐function and gain‐of‐function mutations cause familial hypocalciuric hypercalcaemia (FHH) and autosomal dominant hypocalcaemia (ADH), respectively. CaS receptor signal transduction in the parathyroid glands is probably regulated by G‐protein subunit α11(Gα11) and adaptor‐related protein...

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PMID: 29127708
DOI: 10.1111/bph.14086

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