Article

microCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ System

2017-02-14

Abstract excerpt

<h4>ABSTRACT</h4> Phenomics, which ideally involves in-depth phenotyping at the whole-organism scale, may enhance our functional understanding of genetic variation. Here, we demonstrate methods to profile hundreds of measures comprised of morphological and densitometric traits from a large number sites in the axial skeleton of adult zebrafish. We show the potential for vertebral patterns to confer heightened sens...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b0e5a13e-c7de-5f69-b9eb-65ea7812a03a
DOI: 10.1101/105569

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

microCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ SystemDOI 10.1101/105569Read

Decoding G0 somatic mutants through deep phenotyping and mosaic pattern analysis in the zebrafish skeletonSemantic proximity Read

Bone Phenotyping Approaches in Human, Mice and Zebrafish - Expert Overview of the EU Cost Action GEMSTONE ("GEnomics of MusculoSkeletal traits TranslatiOnal NEtwork").Semantic proximity Read

Microscopic computed tomography-based skeletal phenotyping for genetic model organisms.Semantic proximity Read

Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafishSemantic proximity Read

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases.Semantic proximity Read

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseasesSemantic proximity Read

Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish.Semantic proximity Read

Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms.Semantic proximity Read

High-throughput phenotyping and genetic linkage of cortical bone microstructure in the mouse.Semantic proximity Read

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathiesSemantic proximity Read

Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathiesSemantic proximity Read

Rapid-throughput skeletal phenotyping of 100 knockout mice identifies 9 new genes that determine bone strength.Semantic proximity Read