Article

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases

2022-08-18

Abstract excerpt

Genetic diseases affecting the skeletal system present with a wide range of symptoms that make diagnosis and treatment difficult. Genome-wide association and sequencing studies have identified genes linked to human skeletal diseases. Gene editing of zebrafish models allows researchers to further examine the link between genotype and phenotype, with the long-term goal of improving diagnosis and treatment. While cur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7e7dda88-d941-55bf-9668-76d313a4c579
DOI: 10.1101/2022.08.18.504429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseasesDOI 10.1101/2022.08.18.504429Read

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases.Semantic proximity Read

Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragilitySemantic proximity Read

Decoding G0 somatic mutants through deep phenotyping and mosaic pattern analysis in the zebrafish skeletonSemantic proximity Read

Expanding the phenome and variome of skeletal dysplasia.Semantic proximity Read

Advances in Skeletal Dysplasia Genetics.Semantic proximity Read

Diagnostic Yield of Rare Skeletal Dysplasia Conditions in the Radiogenomics Era – A UK ExperienceSemantic proximity Read

Molecular Landscape in Limb Anomalies: Diagnostic Yield and New Candidate Genes.Semantic proximity Read

Using Zebrafish to Test the Genetic Basis of Human Craniofacial Diseases.Semantic proximity Read

Diagnostic yield of rare skeletal dysplasia conditions in the radiogenomics era.Semantic proximity Read

Skeleton Genetics: a comprehensive database for genes and mutations related to genetic skeletal disorders.Semantic proximity Read

microCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ SystemSemantic proximity Read

The transcriptome of regenerating zebrafish scales identifies genes involved in human bone diseaseSemantic proximity Read