Article

Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish

2021-02-12

Abstract excerpt

Due to the complexity of fish skulls, previous attempts to classify craniofacial phenotypes have relied on qualitative features or 2D landmarks. In this work we aim to identify and quantify differences in 3D craniofacial phenotypes in adult zebrafish mutants. We first estimate a synthetic ‘normative’ zebrafish template using microCT scans from a sample pool of wildtype animals using the Advanced Normalization Tool...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4729859-72aa-5566-b961-3dc71f93c88f
DOI: 10.1101/2021.02.12.431035

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafishDOI 10.1101/2021.02.12.431035Read

Computational anatomy and geometric shape analysis enables analysis of complex craniofacial phenotypes in zebrafish.Semantic proximity Read

Morphometric analyses of shape: The analysis software toolbox for quantification of craniofacial shapeSemantic proximity Read

microCT-Based Phenomics in the Zebrafish Skeleton Reveals Virtues of Deep Phenotyping in a Distributed Organ SystemSemantic proximity Read

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseases.Semantic proximity Read

Examining craniofacial variation among crispant and mutant zebrafish models of human skeletal diseasesSemantic proximity Read

Geometric Morphometrics on Gene Expression Patterns Within Phenotypes: A Case Example on Limb Development.Semantic proximity Read

Automatic Body Morphometric Analysis of Adult Zebrafish Using MicroCTSemantic proximity Read

Cichlid fishes as a model to understand normal and clinical craniofacial variation.Semantic proximity Read

Mapping of Craniofacial Traits in Outbred Mice Identifies Major Developmental Genes Involved in Shape Determination.Semantic proximity Read

Utility of quantitative micro-computed tomographic analysis in zebrafish to define gene function during skeletogenesis.Semantic proximity Read

zFACE: Facial Analytics from a Coordinate Extrapolation System for Developing ZebrafishSemantic proximity Read

Phenotypic variability and craniofacial dysmorphology: increased shape variance in a mouse model for cleft lip.Semantic proximity Read