Article

Characterization of the somatic landscape and transcriptional profile of breast tumors from 748 Hispanic/Latina women in California

2026-02-17

Abstract excerpt

<h4>ABSTRACT</h4> Somatic mutations and the tumor immune microenvironment (TIME) in breast tumors are important predictors of treatment response and survival, yet data for Hispanic/Latina (H/L) women are limited. Here we analyzed whole exome sequencing data from tumor/normal pairs and RNAseq data from 748 H/L women and 388 non-Hispanic White (NHW) women. Despite very similar somatic mutational and copy number pro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 667ccc18-fff2-52fb-ae5d-3fd8e8febf92
DOI: 10.64898/2026.02.13.26346286

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Characterization of the somatic landscape and transcriptional profile of breast tumors from 748 Hispanic/Latina women in CaliforniaDOI 10.64898/2026.02.13.26346286Read

The breast pre-cancer atlas illustrates the molecular and micro-environmental diversity of ductal carcinoma in situSemantic proximity Read

Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics.Semantic proximity Read

APOBEC in breast cancer: a dual player in tumor evolution and therapeutic responseSemantic proximity Read

Comprehensive omic characterization of breast cancer in Mexican-Hispanic women.Semantic proximity Read

APOBEC3 mutagenesis drives therapy resistance in breast cancerSemantic proximity Read

Mutation burden-orthogonal tumor genomic subtypes delineate responses to immune checkpoint therapySemantic proximity Read

Defining the regulatory logic of breast cancer using single-cell epigenetic and transcriptome profilingSemantic proximity Read

Germline <i>APOBEC3B</i> deletion in Asian women increases somatic hypermutation in breast cancer that is associated with Her2 subtype, <i>PIK3CA</i> mutations, immune activation, and increased survivalSemantic proximity Read

Genetic immune escape landscape in primary and metastatic cancerSemantic proximity Read

Integrative genomic analyses of APOBEC-mutational signature, expression and germline deletion of APOBEC3 genes, and immunogenicity in multiple cancer typesSemantic proximity Read

Whole-Genome Landscape of Breast Cancers from India shows Distinct Clinically Actionable SubtypesSemantic proximity Read