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DNA damage response revisited: the p53 family and its regulators provide endless cancer therapy opportunities

7 Oct 2022

Abstract excerpt

Antitumor therapeutic strategies that fundamentally rely on the induction of DNA damage to eradicate and inhibit the growth of cancer cells are integral approaches to cancer therapy. Although DNA-damaging therapies advance the battle with cancer, resistance, and recurrence following treatment are common. Thus, searching for vulnerabilities that facilitate the action of DNA-damaging agents by sensitizing cancer...

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PMID: 36207426
DOI: 10.1038/s12276-022-00863-4

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