Article

Investigating altered limbic reward system in Huntington's Disease: Implications for apathy

2024-02-17

Abstract excerpt

Huntington's disease (HD) is an inherited neurodegenerative condition characterized by motor, cognitive, and behavioral impairments. Apathy, marked by reduced motivation and goal-directed behavior, is the most prevalent psychiatric symptom in HD, impacting both patients and caregivers. Traditionally linked to executive dysfunction within the dorsolateral prefrontal cortex (dlPFC)-dorsal striatum loop in HD, the ro...

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Literature Corpus work: b078e2fa-4e5f-52c9-8d9c-2b46dfcf3dee
DOI: 10.1101/2024.02.13.580195

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