Article

Understanding the role of dopamine in pathology and cognition in Huntington's disease

2020-01-01

Abstract excerpt

Huntington’s disease is a genetic neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin gene. Dysfunction of dopamine (DA) signalling is thought to drive several of its clinical manifestations. DA receptors in frontostriatal pathways are lost early in the disease course – a possible compensatory response to increased dopaminergic activity, which is responsible for the hyperkinetic movement d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d699cfcd-fc04-5697-b33f-138928035c2f
DOI: 10.17863/cam.62231

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Understanding the role of dopamine in pathology and cognition in Huntington's diseaseDOI 10.17863/cam.62231Read

Dysfunctional striatal dopamine signaling in Huntington's diseaseSemantic proximity Read

Huntington’s disease and striatal signalingSemantic proximity Read

Huntington’s Disease: From Genetics to TherapeuticsSemantic proximity Read

Huntington disease: a single-gene degenerative disorder of the striatumSemantic proximity Read

Huntington's disease: the coming of age.Semantic proximity Read

Recent approaches on Huntington's disease (Review)Semantic proximity Read

Antidepressants and Slower Disease Progression in Huntington’s DiseaseSemantic proximity Read

Molecular Imaging Markers to Track Huntington’s Disease PathologySemantic proximity Read

Therapeutics Advancement for Huntington DiseaseSemantic proximity Read

Therapeutic Advances for Huntington’s DiseaseSemantic proximity Read

Huntington's disease: From molecular basis to therapeutic advances.Semantic proximity Read

Genetics and neuropathology of Huntington's disease.Semantic proximity Read