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Article

Delay Discounting of Reward and Caudate Nucleus Volume in Individuals with α-Synuclein Gene Duplication before and after the Development of Parkinson’s Disease

3 Oct 2012

Abstract excerpt

BACKGROUND/AIMS: α-Synuclein (SNCA) may be a key factor in dopaminergic neurotransmission, reward processing, and neurodegeneration in Parkinson's disease (PD). We investigated delay discounting of reward and caudate volume in SNCA gene duplication carriers before and after the development of PD. METHODS: Participants were 7 presymptomatic SNCA duplication carriers who later developed PD (follow-up period: 5.4...

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PMID: 23038403
DOI: 10.1159/000341997

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