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Article

Dissociable Motivational Deficits in Pre-manifest Huntington's Disease.

Cell reports. Medicine - 22 Dec 2020

Atkins Kelly J, Andrews Sophie C, Stout Julie C, Chong Trevor T-J

Abstract excerpt

Motivation is characterized by a willingness to overcome both cognitive and physical effort costs. Impairments in motivation are common in striatal disorders, such as Huntington's disease (HD), but whether these impairments are isolated to particular domains of behavior is controversial. We ask whether HD differentially affects the willingness of individuals to overcome cognitive versus physical effort. We tested...

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Identifiers

PMID: 33377123
DOI: 10.1016/j.xcrm.2020.100152
PMCID: PMC7762769

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