Article

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infection

2021-09-08

Abstract excerpt

Cigarette smoking has multiple serious negative health consequences. However, the epidemiological relationship between cigarette smoking and SARS-CoV-2 infection is controversial; and the interaction between cigarette smoking, airway expression of the ACE2 receptor and the susceptibility of airway cells to infection is unclear. We exposed differentiated air-liquid interface cultures derived from primary human airw...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b06c5ef4-7fa6-5246-af32-c4ea9717958d
DOI: 10.1101/2021.09.08.459428

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infectionDOI 10.1101/2021.09.08.459428Read

Cigarette Smoke Preferentially Induces Full Length ACE2 Expression in Differentiated Primary Human Airway Cultures But Does Not Alter Susceptibility to SARS-CoV-2 InfectionSemantic proximity Read

Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tractSemantic proximity Read

Expression of the SARS-CoV-2 <i>ACE2</i> Receptor in the Human Airway EpitheliumSemantic proximity Read

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair responseSemantic proximity Read

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory TractSemantic proximity Read

Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infectionSemantic proximity Read

ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19Semantic proximity Read

Smoking and COVID ‐19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokersSemantic proximity Read

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cellSemantic proximity Read

Role of Cigarette Smoke on ACE-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface ModelSemantic proximity Read

Increased expression of ACE2, the SARS-CoV-2 entry receptor, in alveolar and bronchial epithelium of smokers and COPD subjectsSemantic proximity Read

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2Semantic proximity Read