Article

Cigarette Smoke Preferentially Induces Full Length ACE2 Expression in Differentiated Primary Human Airway Cultures But Does Not Alter Susceptibility to SARS-CoV-2 Infection

2022-10-06

Abstract excerpt

Cigarette smoking has many serious negative health consequences. The relationship between smoking and SARS-CoV-2 infection is controversial, specifically whether smokers are at increased risk of infection. We investigated the impact of cigarette smoke on ACE2 isoform expression and SARS-CoV-2 infection in differentiated primary human bronchial epithelial cells at the air-liquid-interface (ALI). We assessed the exp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8fc858b6-6279-582f-b172-f847972dcdf6
DOI: 10.2139/ssrn.4220981

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cigarette Smoke Preferentially Induces Full Length ACE2 Expression in Differentiated Primary Human Airway Cultures But Does Not Alter Susceptibility to SARS-CoV-2 InfectionDOI 10.2139/ssrn.4220981Read

Cigarette smoke preferentially induces full length ACE2 exposure in primary human airway cells but does not alter susceptibility to SARS-CoV-2 infectionSemantic proximity Read

Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tractSemantic proximity Read

Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory TractSemantic proximity Read

ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19Semantic proximity Read

Expression of the SARS-CoV-2 <i>ACE2</i> Receptor in the Human Airway EpitheliumSemantic proximity Read

Role of Cigarette Smoke on ACE-2 Protein Membrane Expression in Bronchial Epithelial Cells Using an Air-Liquid Interface ModelSemantic proximity Read

Smoking and COVID ‐19: Similar bronchial ACE2 and TMPRSS2 expression and higher TMPRSS4 expression in current versus never smokersSemantic proximity Read

Expression of ACE2, TMPRSS2 and CTSL in human airway epithelial cells under physiological and pathological conditions: Implications for SARS-CoV-2 infectionSemantic proximity Read

Direct exposure to SARS-CoV-2 and cigarette smoke increases infection severity and alters the stem cell-derived airway repair responseSemantic proximity Read

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cellSemantic proximity Read

Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2Semantic proximity Read

Tobacco, but not nicotine and flavor-less electronic cigarettes, induces ACE2 and immune dysregulationSemantic proximity Read