Article

Lovastatin Dismantles the HMGCR/CD44 Axis to Halt Gastric Carcinogenesis

2026-04-28

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Chronic atrophic gastritis (CAG) is a well-recognized precancerous stage in the Correa cascade leading to gastric cancer (GC). However, the molecular mechanisms driving CAG-to-GC transformation remain incompletely understood. Here we elucidate a cholesterol-fuelled HMGCR/CD44 metabolic–stemness axis that orchestrates the entire transition and show that it can...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b063d3a3-da9e-596f-874d-2dd7fed26887
DOI: 10.21203/rs.3.rs-9272874/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lovastatin Dismantles the HMGCR/CD44 Axis to Halt Gastric CarcinogenesisDOI 10.21203/rs.3.rs-9272874/v1Read

Statins’ Regulation of the Virulence Factors of Helicobacter pylori and the Production of ROS May Inhibit the Development of Gastric CancerSemantic proximity Read

Targeting Mevalonate Pathway Enhances the efficacy of 5-Fluorouracil by regulating pyroptosisSemantic proximity Read

Mitochondrial Acetyl‐CoA Synthetase 3 is Biosignature of Gastric Cancer ProgressionSemantic proximity Read

Targeting HIF-2α in Colorectal Cancer Reveals a Cholesterol Biosynthesis–Dependent Ferroptotic VulnerabilitySemantic proximity Read

The Safe Soluble Compound Dehydroascorbic Acid Inhibits Various Upstream and Downstream Effectors of PI3K and KRAS Signaling Pathways in Undruggable PIK3CA/KRAS-Mutant Colorectal Cancer Stem-Like Cells.Semantic proximity Read

Combinatorial treatment with statins and niclosamide prevents CRC dissemination by unhinging the MACC1-β-catenin-S100A4 axis of metastasisSemantic proximity Read

Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathwaySemantic proximity Read

Inhibiting HMGCR represses stemness and metastasis of hepatocellular carcinoma via Hedgehog signalingSemantic proximity Read

Bile Acids Serve As Endogenous Antagonists Of The Leukemia Inhibitory Factor (LIF) Receptor in OncogenesisSemantic proximity Read

Lipophilic statins antagonistically alter the major epithelial‐to‐mesenchymal transition signaling pathways in breast cancer stem–like cells via inhibition of the mevalonate pathwaySemantic proximity Read

Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells.Semantic proximity Read

Deanticoagulated Heparins Mediate Goblet Cell Differentiation to Restore Mucosal Barrier for Ulcerative Colitis TherapySemantic proximity Read