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Article

Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells.

Infection and immunity - 1 Jul 2008

Lai Chih-Ho, Chang Yun-Chieh, Du Shin-Yi, Wang Hung-Jung, Kuo Chun-Hsien, Fang Shih-Hua, Fu Hua-Wen, Lin Hui-Hao, Chiang Ann-Shyn, Wang Wen-Ching

Abstract excerpt

Infection with Helicobacter pylori cagA-positive strains is associated with gastritis, ulcerations, and gastric cancer. CagA is translocated into infected epithelial cells by a type IV secretion system and can be tyrosine phosphorylated, inducing signal transduction and motogenic responses in epi...

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Source

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Identifiers

PMID: 18443091
DOI: 10.1128/IAI.00365-08
PMCID: PMC2446742

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18443091-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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