Lovastatin lactone may improve irritable bowel syndrome with constipation (IBS-C) by inhibiting enzymes in the archaeal methanogenesis pathway

Abstract excerpt

Methane produced by the methanoarchaeon Methanobrevibacter smithii ( M. smithii ) has been linked to constipation, irritable bowel syndrome with constipation (IBS-C), and obesity. Lovastatin, which demonstrates a cholesterol-lowering effect by the inhibition of HMG-CoA reductase, may also have an anti-methanogenesis effect through direct inhibition of enzymes in the archaeal methanogenesis pathway. We conducted...

Topics

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• Diet and metabolism studies
• Gastrointestinal motility and disorders
• Gut microbiota and health
• Hormonal Regulation and Hypertension
• Nutrition, Genetics, and Disease
• Pharmacogenetics and Drug Metabolism
• Probiotics and Fermented Foods
• Steroid Chemistry and Biochemistry

Identifiers and source

Literature Corpus work

7a403097-af3b-5cdd-bd8f-10c10c6b8a9f

DOI

10.12688/f1000research.8406.3