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SWI/SNF complex-mediated chromatin remodeling in Candida glabrata promotes immune evasion

26 Mar 2024

Abstract excerpt

Immune evasion is critical for fungal virulence. However, how the human opportunistic pathogen Candida glabrata ( Cg ) accomplishes this is unknown. Here, we present the first genome-wide nucleosome map of the macrophage-internalized Cg consisting of ∼12,000 dynamic and 70,000 total nucleosomes. We demonstrate that CgSnf2 (SWI/SNF chromatin remodeling complex-ATPase subunit)-mediated chromatin reorganization in...

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PMID: 38632999
DOI: 10.1016/j.isci.2024.109607

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