SWI/SNF complex-mediated chromatin remodelling in <i>Candida glabrata</i> is vital for immune evasion

Abstract excerpt

Immune evasion is critical for fungal virulence. However, how the human opportunistic pathogen Candida glabrata ( Cg ) accomplishes this is unknown. Here, using micrococcal nuclease-sequencing, RNA-sequencing, macrophage-signalling and genetic analyses, we demonstrate that chromatin reorganization in macrophage-internalized Cg , via CgSnf2 (ATPase subunit of the SWI/SNF chromatin remodelling complex), leads to...

Topics

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• Antifungal resistance and susceptibility
• Fungal and yeast genetics research
• Fungal Infections and Studies
• Infectious Diseases and Mycology
• Peptidase Inhibition and Analysis
• Plant Disease Resistance and Genetics
• Probiotics and Fermented Foods
• Research on Leishmaniasis Studies

Identifiers and source

Literature Corpus work

9fc75f5f-be0b-593e-9794-af293ce20605

DOI

10.1101/2023.04.15.536997