Article
An Architect of the Hindbrain: DDX3X Regulates Normal and Malignant Development.
Developmental cell - 24 Aug 2020
Hwang Grace H, Segal Rosalind A
Abstract excerpt
Hallmark mutations in WNT and SHH medulloblastoma are usually distinct, but DDX3X is often mutated in both subgroups. In this issue of Developmental Cell, Patmore et al. identify Ddx3x as essential for hindbrain patterning, cell fate determination, and as a tumor suppressor gene that restricts cell lineage progression in tumorigenesis.
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