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IL-1α drives a tumor-stroma-neutrophil axis through inflammatory fibroblast activation in head and neck cancer

2026-01-22

Abstract excerpt

In head and neck squamous cell carcinoma (HNSCC), high tumor-associated neutrophil (TAN) density is a robust biomarker of poor prognosis. TANs predominantly localize to the stroma and their intratumoral density strongly correlates with adverse outcome. Here, we investigated how tumor-stroma communication regulates TAN recruitment, activation, and spatial organization. We identified interleukin-1α (IL-1α), released...

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Literature Corpus work
b0190006-86c6-5f0b-aa8e-73daa167f86e
DOI
10.64898/2026.01.20.700440
Open publication

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IL-1α drives a tumor-stroma-neutrophil axis through inflammatory fibroblast activation in head and neck cancerDOI 10.64898/2026.01.20.700440
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