Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas

1 Feb 2022

Abstract excerpt

Plexiform neurofibromas (pNFs) are developmental tumors that appear in neurofibromatosis type 1 individuals, constituting a major source of morbidity and potentially transforming into a highly metastatic sarcoma (MPNST). pNFs arise after NF1 inactivation in a cell of the neural crest (NC)-Schwann cell (SC) lineage. Here, we develop an iPSC-based NC-SC in vitro differentiation system and construct a lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Meningioma and schwannoma management
Share to Neurofibromatosis and Schwannoma Cases
Share to Sarcoma Diagnosis and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35172160
DOI: 10.1016/j.celrep.2022.110385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromasPMID 35172160Read ↗

Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform NeurofibromasSemantic proximity Read ↗

Humanized neurofibroma model from induced pluripotent stem cells delineates tumor pathogenesis and developmental origins.Semantic proximity Read ↗

A novel induced pluripotent stem cell model of Schwann cell differentiation reveals <i>NF2</i> - related gene regulatory networks of the extracellular matrixSemantic proximity Read ↗

Single-Cell Analysis of <i>NF1</i> -Expressing and <i>NF1</i> -Deficient Schwann and Fibroblast Cells Reveals Divergent Neurofibroma ProgramsSemantic proximity Read ↗

An induced pluripotent stem cell model of Schwann cell differentiation reveals NF2- related gene regulatory networksSemantic proximity Read ↗

Integration of single-nuclei RNA-sequencing, spatial transcriptomics and histochemistry defines the complex microenvironment of NF1-associated plexiform neurofibromasSemantic proximity Read ↗

iPSC-derived <i>NF1</i> - <i>CDKN2A</i> -PRC2 deficient neural crest mimics MPNST glial-to-neuro-mesenchymal transition and uncover new therapeutic opportunitiesSemantic proximity Read ↗

How does the Schwann cell lineage form tumors in NF1?Semantic proximity Read ↗

TGFβ-dependent signaling drives tumor growth and aberrant extracellular matrix dynamics in NF1-associated plexiform neurofibromaSemantic proximity Read ↗

Neurofibroma Development in Neurofibromatosis Type 1: Insights from Cellular Origin and Schwann Cell Lineage DevelopmentSemantic proximity Read ↗

Pathogenesis of Plexiform Neurofibroma: Tumor-Stromal/Hematopoietic Interactions in Tumor ProgressionSemantic proximity Read ↗

Spatiotemporal Loss of NF1 in Schwann Cell Lineage Leads to Different Types of Cutaneous Neurofibroma Susceptible to Modification by the Hippo PathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.