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Article

Interactions among Merlin, Arkadia, and SKOR2 mediate NF2-associated human Schwann cell proliferation.

Stem cell research & therapy - 5 Apr 2025

Tang Pei-Ciao, Um Seyoung, Mayfield Anderson B, Bracho Olena R, Castillo Christian Del, Dinh Christine T, Dykxhoorn Derek M, Liu Xue Zhong

Abstract excerpt

BACKGROUND: NF2-related Schwannomatosis (previously referred to as Neurofibromatosis Type 2, or NF2) is a genetic-associated disease resulting from mutations in the gene, NF2. NF2 encodes the Merlin protein, which acts as a tumor suppressor. Bilateral vestibular schwannoma (VS) is a hallmark of NF2. Although the exactly molecular mechanism mediating NF2-driven schwannomatosis is not fully understood, it is known...

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Identifiers

PMID: 40188079
DOI: 10.1186/s13287-025-04281-x
PMCID: PMC11972516

Genes

NF2
SKOR2
SKI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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