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Ionomycin Ameliorates Hypophosphatasia <i>via</i> Rescuing Alkaline Phosphatase Deficiency-mediated L-type Ca <sup>2+</sup> Channel Internalization in Mesenchymal Stem Cells

2019-02-08

Abstract excerpt

Loss-of-function mutations in ALPL result in hypophosphatasia (HPP), an inborn error of metabolism that causes skeletal mineralization defect. In adults, main clinical involvement includes early loss of primary or secondary teeth, osteoporosis, bone pain, chondrocalcinosis, and fractures. However, guidelines for the treatment of adults with HPP are not available. Here, we show that ALPL deficiency caused reduction...

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Literature Corpus work
aff21a6a-f77a-5919-b346-80e03eb49d9d
DOI
10.1101/545418
Open publication

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Ionomycin Ameliorates Hypophosphatasia <i>via</i> Rescuing Alkaline Phosphatase Deficiency-mediated L-type Ca <sup>2+</sup> Channel Internalization in Mesenchymal Stem CellsDOI 10.1101/545418
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