Article

Allelic bias when performing in-solution enrichment of ancient human DNA

2023-07-05

Abstract excerpt

In-solution hybridisation enrichment of genetic variation is a valuable methodology in human paleogenomics. It allows enrichment of endogenous DNA by targeting genetic markers that are comparable between sequencing libraries. Many studies have used the 1240k reagent—which enriches 1,237,207 genome-wide SNPs—since 2015, though access was restricted. In 2021, Twist Biosciences and Daicel Arbor Biosciences independen...

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Literature Corpus work: afdb7021-907d-5b3e-8e6b-0d2bc4133079
DOI: 10.1101/2023.07.04.547445

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