Article

Integrating pharmacogenomics and cheminformatics with diverse disease phenotypes for cell type-guided drug discovery

2022-12-22

Abstract excerpt

Large-scale pharmacogenomic resources, such as the Connectivity Map (CMap), have greatly assisted computational drug discovery. However, despite their widespread use, CMap-based methods have thus far been agnostic to the biological activity of drugs, as well as to the genomic effects of drugs in multiple disease contexts. Here, we present a network-based statistical approach, Pathopticon, that uses CMap to build c...

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Literature Corpus work: afd43974-861c-598e-a55c-1ed1ce9cc865
DOI: 10.1101/2022.12.21.521456

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