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Article

The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition.

Toxicology and applied pharmacology - 15 Jan 2021

Chen Jinglou, Rong Nan, Liu Min, Xu Congyue, Xiong Qi, Lei Yongfang

Abstract excerpt

Benign prostatic hyperplasia (BPH) is an age-related disease in men. Mesenchymal /stromal and epithelial cells interactions are essential to prostate functions. In this study, human nonmalignant prostate epithelial RWPE-1 cells were cocultured with testosterone (TE) -exposed prostate stromal fibroblasts WPMY-1 cells (TE-WPMY-1). The survival rate, epithelial-mesenchymal transition (EMT) and collagen deposition of...

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Identifiers

PMID: 33359661
DOI: 10.1016/j.taap.2020.115384

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