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Engineered model of t(7;12)(q36;p13) AML recapitulates patient-specific features and gene expression profiles

3 Sept 2022

Abstract excerpt

Acute myeloid leukaemia carrying the translocation t(7;12)(q36;p13) is an adverse-risk leukaemia uniquely observed in infants. Despite constituting up to 30% of cases in under 2-year-olds, it remains poorly understood. Known molecular features are ectopic overexpression of the MNX1 gene and generation of a fusion transcript in 50% of patients. Lack of research models has hindered understanding of t(7;12) biology,...

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PMID: 36057683
DOI: 10.1038/s41389-022-00426-2

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