Article
Characterization of aromatic residue-controlled protein retention in the endoplasmic reticulum of Saccharomyces cerevisiae.
The Journal of biological chemistry - 15 Dec 2017
Mei Meng, Zhai Chao, Li Xinzhi, Zhou Yu, Peng Wenfang, Ma Lixin, Wang Qinhong, Iverson Brent L, Zhang Guimin, Yi Li
Abstract excerpt
An endoplasmic reticulum (ER) retention sequence (ERS) is a characteristic short sequence that mediates protein retention in the ER of eukaryotic cells. However, little is known about the detailed molecular mechanism involved in ERS-mediated protein ER retention. Using a new surface display-based fluorescence technique that effectively quantifies ERS-promoted protein ER retention within Saccharomyces cerevisiae...
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