Article

Evaluation of Hi-C sequencing for the detection of gene fusions in hematologic and solid pediatric cancer samples

2024-05-12

Abstract excerpt

HiC sequencing is a DNA-based next-generation sequencing method that preserves the 3D conformation of the genome and has shown promise in detecting genomic rearrangements in translational research studies. To evaluate HiC as a potential clinical diagnostic platform, analytical concordance with routine laboratory testing was assessed using primary pediatric leukemia and sarcoma specimens previously positive for cli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7087ddd7-68de-5814-ab9f-37138eed724c
DOI: 10.1101/2024.05.10.24306838

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evaluation of Hi-C sequencing for the detection of gene fusions in hematologic and solid pediatric cancer samplesDOI 10.1101/2024.05.10.24306838Read

Hi-C detects genomic structural variants in peripheral blood of pediatric leukemia patientsSemantic proximity Read

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting.Semantic proximity Read

SJPedPanel: A pan-cancer gene panel for childhood malignanciesSemantic proximity Read

Clinical Validation of a Myeloid Next-Generation Sequencing Panel for Single-Nucleotide Variants, Insertions/Deletions, and Fusion Genes.Semantic proximity Read

Successful classification of clinical pediatric leukemia genetic subtypes via structural variant detection using HiFi long-read sequencingSemantic proximity Read

Development and validation of a comprehensive genomic diagnostic tool for myeloid malignancies.Semantic proximity Read

Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumorsSemantic proximity Read

Comprehensive Validation of Diagnostic Next-Generation Sequencing Panels for Acute Myeloid Leukemia Patients.Semantic proximity Read

Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencingSemantic proximity Read

Enhanced clinical assessment of hematologic malignancies through routine paired tumor:normal sequencingSemantic proximity Read

Genomic alterations in pediatric tumors: clinical relevance and translational insightsSemantic proximity Read

AML with complex karyotype: extreme genomic complexity revealed by combined long-read sequencing and Hi-C technology.Semantic proximity Read