Back to search

Article

High incidence of Y-chromosome mosaicism in male and female individuals with MOGHE

2025-10-19

Abstract excerpt

Mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) is a recently discovered histopathological lesion entity. Approximately half of affected individuals carry a pathogenic brain mosaicism in the X-linked SLC35A2 gene, and all suffer from epilepsy. In this work, we extended the search for genetic alterations of MOGHE by investigating sex chromosome copy number alteration...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
af781faf-09b6-5509-8bfc-d625f4c9214c
DOI
10.1101/2025.10.15.25337897
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
High incidence of Y-chromosome mosaicism in male and female individuals with MOGHEDOI 10.1101/2025.10.15.25337897
Cell type mapping of mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy using single-nucleus multiomicsSemantic proximity
SLC35A2 somatic variants in drug resistant epilepsy: FCD and MOGHESemantic proximity
A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing human brain.Semantic proximity
Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders.Semantic proximity
Genomic mosaicism in the developing and adult brainSemantic proximity
Somatic Mosaicism in Brain Disorders.Semantic proximity
Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firingSemantic proximity
Somatic mosaicism in the diseased brainSemantic proximity
Post-zygotic rescue of meiotic errors causes brain mosaicism and focal epilepsy.Semantic proximity
Slc35a2 mosaic knockout impacts cortical development, dendritic arborisation, and neuronal firing in the developing brainSemantic proximity
Genetic causes underlying grey matter heterotopiaSemantic proximity
Meningiomas: Sex-specific differences and prognostic implications of a chromosome X lossSemantic proximity
Select a neighboring publication to make it the new centre.