Article

Metabolic regulation by prostaglandin E <sub>2</sub> impairs lung group 2 innate lymphoid cell responses

2021-12-24

Abstract excerpt

Group 2 innate lymphoid cells (ILC2s) play a critical role in asthma pathogenesis. Non-steroidal anti-inflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is associated with reduced signaling via EP2, a receptor for prostaglandin E 2 (PGE 2 ). However, the respective roles for the PGE 2 receptors EP2 and EP4 (both share same downstream signaling) in the regulation of lung ILC2 responses has yet been...

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Literature Corpus work: af5ab5ed-ea47-58a5-9e35-eaaa2644e79b
DOI: 10.1101/2021.12.23.474031

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