Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma.

Allergology international : official journal of the Japanese Society of Allergology - 1 Dec 2008

Oguma Tsuyoshi, Asano Koichiro, Ishizaka Akitoshi

Abstract excerpt

Prostaglandin D(2) (PGD(2)) is one of the most abundant lipid mediators present in the airways of asthmatics. However, little was known of the role it plays in the pathophysiology of asthma, until the identification of DP (DP1, PTGDR) and CRTH2 (DP2), two PGD(2)-specific transmembrane receptors with different distribution and intracellular signaling. Pharmacological tools, such as receptor-specific agonists and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma
Share to Ethnicity
Share to Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Promoter Regions, Genetic

Share to Receptors, Immunologic

Share to Receptors, Prostaglandin

Share to Signal Transduction

Source

Identifiers

PMID: 18946232
DOI: 10.2332/allergolint.08-RAI-0033

Genes

PGD
PTGDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma.PMID 18946232Read ↗

Expression of DP2 (CRTh2), a Prostaglandin D2 Receptor, in Human Mast CellsSemantic proximity Read ↗

The prostaglandin D2 receptor (PTGDR) gene in asthma and allergic diseases.Semantic proximity Read ↗

Emerging roles of DP and CRTH2 in allergic inflammationSemantic proximity Read ↗

The role of prostaglandin D receptor gene in asthma pathogenesis.Semantic proximity Read ↗

Prostaglandin regulation of type 2 inflammation: From basic biology to therapeutic interventionsSemantic proximity Read ↗

Cutting Edge: Chemoattractant Receptor-Homologous Molecule Expressed on TH2 Cells Plays a Restricting Role on IL-5 Production and Eosinophil RecruitmentSemantic proximity Read ↗

PTGDR polymorphisms and susceptibility to asthma: a meta-analysis.Semantic proximity Read ↗

International Union of Basic and Clinical Pharmacology. CIX. Differences and Similarities between Human and Rodent Prostaglandin E2 Receptors (EP1-4) and Prostacyclin Receptor (IP): Specific Roles in Pathophysiologic Conditions.Semantic proximity Read ↗

Aspirin-exacerbated respiratory disease: an update.Semantic proximity Read ↗

Elevated levels of circulating CD4(+) CRTh2(+) T cells characterize severe asthma.Semantic proximity Read ↗

Differential control of T-cell subsets by recombinant human PLD2 in a mouse model of allergic asthmaSemantic proximity Read ↗

PTGDR gene in asthma: a functional, genetic, and epigenetic study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.