Novel missense mutation in the NOD2 gene in a patient with early onset ulcerative colitis: causal or chance association?

Abstract excerpt

Deregulated immune response to gut microflora in genetically predisposed individuals is typical for inflammatory bowel diseases. It is reasonable to assume that genetic association with the disease will be more pronounced in subjects with early onset than adult onset. The nucleotide-binding oligomerization domain containing-2 gene, commonly involved in multifactorial risk of Crohn's disease, and interleukin 10...

Topics

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• Age of Onset
• Colitis, Ulcerative
• Crohn Disease
• DNA Mutational Analysis
• Mutation, Missense