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Chaperone-mediated autophagy as a modulator of aging and longevity

2 Dec 2024

Abstract excerpt

Chaperone-mediated autophagy (CMA) is the lysosomal degradation of individually selected proteins, independent of vesicle fusion. CMA is a central part of the proteostasis network in vertebrate cells. However, CMA is also a negative regulator of anabolism, and it degrades enzymes required for glycolysis, de novo lipogenesis, and translation at the cytoplasmic ribosome. Recently, CMA has gained attention as a...

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PMID: 39687864
DOI: 10.3389/fragi.2024.1509400

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