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α-synucleinopathy associated calcium overload and autophagy failure is regulated by gain-of-function of Tousled-like kinase

2022-07-18

Abstract excerpt

As a pathological hallmark in Parkinson’s disease (PD), α-synucleinopathy causes multiple cellular damages, including calcium overload, mitochondrial and autophagic dysfunction, and eventually dopamine neuron death. However, the hierarchy of these detrimental events is unclear. In Drosophila , we confirmed that overexpression of α-synuclein could induce all these cytotoxic events. To determine the specific cytoto...

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Identifiers and source

Literature Corpus work
6b8c9636-b586-5c6b-b663-24cddf6e18c9
DOI
10.1101/2022.07.17.500360
Open publication

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α-synucleinopathy associated calcium overload and autophagy failure is regulated by gain-of-function of Tousled-like kinaseDOI 10.1101/2022.07.17.500360
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