Article

A new ferrocene derivative blocks KRAS localization and function by oxidative modification at His95

2023-03-29

Abstract excerpt

Ras proteins are membrane-bound GTPases that regulate essential cellular processes at the plasma membrane (PM). Constitutively active mutations of K-Ras, one of the three Ras isoforms in mammalian cells, are frequently found in human cancers. Ferrocene derivatives, which elevate cellular reactive oxygen species (ROS), have shown to block the growth of non-small cell lung cancers (NSCLCs) harboring oncogenic mutant...

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Literature Corpus work: af32ca93-1e17-5f05-91f3-acd5c1d3a116
DOI: 10.1101/2023.03.28.534499

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