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Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation

29 Nov 2022

Abstract excerpt

Abstract Oncogenic KRAS is the key driver oncogene for several of the most aggressive human cancers. One key feature of oncogenic KRAS expression is an early increase in cellular reactive oxygen species (ROS) which promotes cellular transformation if cells manage to escape cell death, mechanisms of which remain incompletely understood. Here, we identify that expression of oncogenic as compared to WT KRAS in...

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PMID: 36443441
DOI: 10.1038/s41418-022-01096-8

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