Back to search

Article

Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons

2023-06-30

Abstract excerpt

<h4>ABSTRACT</h4> Venezuelan Equine Encephalitis virus ( VEEV) may enter the central nervous system (CNS) within olfactory sensory neurons (OSN) that originate in the nasal cavity after intranasal exposure. While it is known that VEEV has evolved several mechanisms to inhibit type I interferon (IFN) signaling within infected cells, whether this inhibits virologic control during neuroinvasion along OSN has not be...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
af26e396-d8b6-5851-8a54-59393182f603
DOI
10.1101/2023.06.30.547169
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neuronsDOI 10.1101/2023.06.30.547169
Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in miceSemantic proximity
Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infectionSemantic proximity
Type I/type III IFN and related factors regulate JEV infection and BBB endothelial integritySemantic proximity
Long-term persistence of viral RNA and inflammation in the CNS of macaques exposed to aerosolized Venezuelan equine encephalitis virusSemantic proximity
Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus EncephalitisSemantic proximity
Identification of host lncRNAs that impact Venezuelan equine encephalitis virus replicationSemantic proximity
EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell DeathSemantic proximity
A mouse model to study Río Negro virus pathogenesis: a neglected member of the Venezuelan equine encephalitis virus complexSemantic proximity
Heterogeneity of Antiviral Responses in the Upper Respiratory Tract Mediates Differential Non-lytic Clearance of Influenza VirusesSemantic proximity
The transcriptional landscape of Venezuelan equine encephalitis virus (TC-83) infectionSemantic proximity
Similarities and Differences in Antagonism of Neuron Alpha/Beta Interferon Responses by Venezuelan Equine Encephalitis and Sindbis AlphavirusesSemantic proximity
Deep spatial profiling of Venezuelan equine encephalitis virus reveals increased genetic diversity amidst neuroinflammation and cell death during brain infection.Semantic proximity
Select a neighboring publication to make it the new centre.