Article

A mouse model to study Río Negro virus pathogenesis: a neglected member of the Venezuelan equine encephalitis virus complex

2026-01-30

Abstract excerpt

Río Negro virus (RNV) is an enzootic alphavirus and a member of the Venezuelan equine encephalitis virus (VEEV) complex. Despite its wide circulation in South America, RNV remains a neglected pathogen with no established wild-type animal model to study its pathogenesis. In this study, we developed a lethal mouse model using 18-day-old wild-type C57BL/6 mice to characterize the systemic and neurological features of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2ab27b05-f6b6-555e-a738-0842999e28a2
DOI: 10.64898/2026.01.29.702336

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A mouse model to study Río Negro virus pathogenesis: a neglected member of the Venezuelan equine encephalitis virus complexDOI 10.64898/2026.01.29.702336Read

Rift Valley Fever Virus Encephalitis: Viral and Host Determinants of PathogenesisSemantic proximity Read

Modelling tick-borne encephalitis in infant rat mimics important aspects of human diseaseSemantic proximity Read

Comparative pathogenesis of two lineages of Powassan virus reveals distinct clinical outcome, neuropathology, and inflammationSemantic proximity Read

Venezuelan equine encephalitis virus infection causes modulation of inflammatory and immune response genes in mouse brainSemantic proximity Read

Understanding host responses to equine encephalitis virus infection: implications for therapeutic developmentSemantic proximity Read

Comparative Pathogenesis of Two Lineages of Powassan Virus Reveals Distinct Clinical Outcome, Neuropathology, and InflammationSemantic proximity Read

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent miceSemantic proximity Read

Single-cell and spatiotemporal transcriptomic profiling of brain immune infiltration following Venezuelan equine encephalitis virus infectionSemantic proximity Read

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice.Semantic proximity Read

A Mouse Model of SARS-CoV-2-Driven Acute Maladaptive Responses and Chronic Systemic DiseasesSemantic proximity Read

Multimodal Profiling of Immune Responses Reveals Innate-Adaptive Immune Imbalance in Human Bornavirus EncephalitisSemantic proximity Read

Pathological Features of Echovirus-11-Associated Brain Damage in Mice Based on RNA-Seq AnalysisSemantic proximity Read